https://www.nicewiczlaboratory.com/biography daily 0.75 2024-07-01 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/e3695b81-4778-4a42-ba2b-3f57555033fb/iufjwdY6S2%2BE846bNQCjBQ_thumb_2f75.jpg Biography - Dave Nicewicz William R. Kenan Jr. Distinguished Professor CB#3290, Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3290, USA nicewicz@unc.edu +1 919 843 9150 Director of Chemistry Graduate Studies (2015-2021) Co-Founder, LED Radiofluidics Synlett Associate Editor Curriculum Vitae Lab Twitter Account NCBI Publications Google Scholar Site What I’m eating, imbibing or city I’m in now https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/62e2d3c7-0690-4ea8-942b-0ffcf9f6eb8f/UNADJUSTEDNONRAW_thumb_291.jpg Biography - Education Dave completed his Bachelor’s (2000) and Master’s (2001) degrees in Chemistry at the University of North Carolina at Charlotte with Professor Craig A. Ogle. He then moved to the University of North Carolina at Chapel Hill where he completed his Ph.D. in 2006 with Professor Jeffrey S. Johnson. His graduate research focused on novel Brook Rearrangement transformations and completed the total synthesis of Zaragozic Acid C. Following his graduate education, Nicewicz was a Ruth L. Kirschstein Postdoctoral Fellow in the laboratories of the 2021 Chemistry Nobel Laureate, Professor David W. C. MacMillan. It was during this time that Nicewicz pioneered the use of ruthenium photoredox catalysis in combination with chiral amine organocatalysis to develop a general method for enantioselective aldehyde alkylation and more importantly, establishing photoredox catalysis as an emerging tool in organic synthesis. In 2009, Dave started as an Assistant Professor at the University of North Carolina at Chapel Hill. He was promoted to Associate Professor in 2015, full Professor in 2018 and was named the first Royce Murray Term Professor of Chemistry at UNC Chapel Hill in 2020. https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/c9b7af31-fa25-4fea-8ebe-a30f29cc8571/fH2bjdc8SYqqFfAG%25sdn1Q_thumb_3e75.jpg Biography - Honors ACS Cope Scholar Award (2022) Blavatnik National Awards for Young Scientists, Finalist (2019) The Hirata Award, Nagoya University, Japan (2017) Society of Synthetic Organic Chemistry, Japan Lectureship Award (2016) Camille Dreyfus Teacher-Scholar Award (2015) Ruth Hettleman Prize for Artistic and Scholarly Achievement – UNC (2015) Eli Lilly Grantee Award (2015) NSF CAREER Award (2014-2019) Amgen Young Investigator Award (2014) Boehringer Ingelheim New Investigator Award in Organic Chemistry (2013) Junior Faculty Development Award – UNC (2013) Packard Fellowship in Science and Engineering (2012) Thieme Chemistry Journal Award (2012) James Moeser Award for Distinguished Research - UNC (2011) Eli Lilly New Faculty Award (2009) https://www.nicewiczlaboratory.com/organic-photoredox-catalysis daily 0.75 2022-02-24 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/e3caa336-2635-47cd-9039-70c00d02a4ef/Photoredox7.001.jpg Organic Photoredox Catalysis https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/4304d080-5fa1-4903-9a5a-736b19cb63e2/Photoredox4.001.jpeg Organic Photoredox Catalysis - Acridinium Photooxidants We have been researching the use of organic photoredox catalysts for their ability to facilitate one electron processes in a range of organic tranformations. The Fukuzumi acridinium salt, 9-mesitylacridinium, has provided a wealth of new chemical reactivity and represents a truly unique photoredox catalyst scaffold. We’ve studied acridiniums for so long that by now, our lab members should all have tattoos of this structure (that is, if some of us haven’t done it already and not admitted it…). The excited state of these catalysts, a twisted intramolecular charge transfer state, is a potent single electron oxidant, with reduction potentials >+2.0 V vs SCE, capable of arene and alkene oxidation to give reactive cation radicals intermediates. https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/8b37418a-5fba-41c8-91bf-c896fb96a9d4/Photoredox6.001.jpeg Organic Photoredox Catalysis - Acridine Radical Reductants Photophysical studies also led our group to propose that the reduced form of the catalyst, an acridyl radical, can absorb a second photon and achieve a new twisted intramolecular charge transfer state that is highly reducing (-3.36 V vs SCE); this state is more reducing than elemental lithium. This now allows the potent acridinium photooxidant to be employed as a catalytic super reductant in the presence of a sacrificial electron source. This discovery has led to a host of reactivity including challenging haloarene reduction and desulfonylation of sulfonamides. https://www.nicewiczlaboratory.com/reaction-development daily 0.75 2022-02-28 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/4c05c800-5099-499b-ab5d-9bdff41a18de/Alkene_CR.001.jpeg Research - Alkene Cation Radicals Alkene cation radicals accessed via one-electron oxidation of an olefin display unique reactivity. We have harnessed these reactive intermediates for a number of transformations including anti-Markovnikov alkene hydrofunctionalization and difunctionalization as well as polar radical crossover cycloadditions. https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/b5a55efb-3be7-4915-81d6-1ca86f782474/Arene_CR.001.jpeg Research - Arene Cation Radicals We have developed a program on arene C-H and C-O bond functionalization via organic photoredox catalysis. Acridinium photocatalysts are capable of one-electron oxidation of a number of (hetero)aromatics with redox potentials <+2.0 V vs. SCE to accomplish a range of C-H bond functionalization reactions including the addition of azoles and ammonia, alkyl amines and cyanide. We have found that anaerobic conditions promote nucleophilic aromatic substitution of alkoxy groups where azoles, alkyl amines and cyanide can displace the alkoxy group. https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/16bb7c1c-6728-435f-9e5f-fe39d69b3b8f/HAT.001.jpeg Research - Alkane C-H Functionalization Alkane C-H functionalization is possible utilizing organic photoredox catalysis to generate alkyl radical species. We have demonstrated that oxygen-centered radicals, generated upon single electron oxidation of the requisite anions, can act as hydrogen atom abstracting species to accomplish C-H functionalization. Carbamate-protected amines can undergo single electron oxidation and deprotonation adjacent to the nitrogen to allow for alpha-functionalization of carbamate-protected amines and regioselective functionalization of piperizines. https://www.nicewiczlaboratory.com/natural-product-synthesis daily 0.75 2022-03-01 https://www.nicewiczlaboratory.com/members daily 0.75 2025-10-21 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/1644977619692-MV20U3ZAR1YKSXFWRUAY/IMG_0771.jpg Members https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1618497259178-6XJGK9GR6YAVBQL5L519/20140301_Trade-151_012-2.jpg Members https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1607694583486-2PQT0LQ193RL7MCB6DX4/20140228_Trade+151_0046.jpg Members https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1607694644871-IC85FNH781UNZSZEGHDR/Aro+Ha_0428.jpg Members https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1607638148090-Y6OFDI575CM3NQV732RJ/Large+JPG-Aro+Ha_0387.jpg Members https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1607628784608-5D22G9GPLHDSAB2IXC2G/Large+JPG-Aro+Ha_0638.jpg Members https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1589847743861-GWVMBPD7Z7WQRQL9IZZ8/Large+JPG-Aro+Ha_0380.jpg Members https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/008a4add-5d79-4bc7-b85f-43f059b78a00/IMG_1588.jpg Members https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/7ae9e0be-5af2-404a-b7e1-6db8be30028a/IMG_2847.jpeg Members https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/17af89b3-6a21-4261-8db2-13ff48da1ad3/IMG_2824.jpeg Members https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/70ed4316-412b-4fd3-8b3e-700326000a4e/12345.jpg Members https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/01ae1da4-a608-4103-8ac8-5a4a00127d14/IMG_4124.jpeg Members https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/47667669-c778-4d47-9f82-8e05a24807e5/IMG_4123.jpeg Members https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/661f50c9-dd90-4dc8-a991-bafb256c34ed/IMG_4136.jpeg Members https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/af34926a-a6e6-4577-b12d-e813dda12e3d/IMG_7266.jpg Members https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/b009b636-3470-4727-91b1-68f1cd6820f9/IMG_7261+2.jpg Members https://www.nicewiczlaboratory.com/mechanistic-studies daily 0.75 2022-02-28 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/5e4bac79-a907-414b-8d26-5b274b27d7a3/TA.001.jpeg Mechanistic Inquiry - Transient Absorption Spectroscopy Excited states of organic molecules are very short lived, typically only nanoseconds, so to study mechanism, we turn to ultra-fast techniques like transient absorption spectroscopy. Housed in the CHASE research facility in the Department of Chemistry, we have access to nanosecond transient absorption spectroscopy to study excited states of organic catalysts and radical ion intermediates. https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/476be10c-431a-41f1-908e-4ea71166e1af/E_Chem.001.jpeg Mechanistic Inquiry - Cyclic Voltammetry It all starts with moving electrons around and what potentials are required for accessing various redox states. Our laboratory routinely utilizes electrochemistry as a starting point to study mechanism in organic chemistry and we have even measured several hundred redox potentials of common organic molecules to provide a resource to the synthetic community. https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/fecdb2fd-eca4-4f50-8d85-a559e208efb9/DFT.001.jpeg Mechanistic Inquiry - DFT Calculations Sometimes informative mechanistic experiments are too difficult or often impossible to design, so we turn to density functional theory (DFT) calculations. Students learn basic DFT energy calculations, transition state modeling and charge density distribution. https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/624bd4b4-31af-480a-9d7f-ae72e299b9e9/NMR.001.jpeg Mechanistic Inquiry - Kinetics via Photo NMR Acquiring kinetic data via NMR presents a challenge for photochemical reactions - introduction of light to the sample! Fortunately, we have a fiber optic LED setup that allows for in-situ NMR kinetics to allow us to perform classical kinetic studies. https://www.nicewiczlaboratory.com/positron-emission-tomography daily 0.75 2023-01-25 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/8fac0a3f-7a45-4ac0-9ad6-c8bf47c6e9cb/PET.001.jpg Positron Emission Tomography https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/5e92d8b4-dec4-4c6c-8111-c2e42e3202d6/abstract_image_38.jpg Positron Emission Tomography - Direct 18F Labeling of (Hetero)Aromatics We have tamed the reactivity of cation radicals to realize the first C-H/C-18F functionalization of aromatics using 18F fluoride and organic photoredox catalysis. This catalytic method allowed a range of 18F labeling of therapeutic molecules. Aromatic ethers can also be utilized as radiolabeling precursors in photoredox-catalyzed nucleophilic aromatic substitution reactions with 18F anions. https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/f08cc47c-3e1b-420b-9b6f-43e429eaa532/PET1.001.jpeg Positron Emission Tomography - 18F Radiolabeling via Aromatic Halide Interconversion Tracer candidates and therapeutics that contain an aromatic fluoride are excellent candidates for introduction of a radiolabel. What if you could use the fluoroaromatic drug as the radiolabeling precursor? We have reported just such a transformation - 18F radiolabeling via halide interconversion by organic photoredox catalysis - that makes it simple to introduce an 18F radiolabel at the same position it appears in the molecule of interest. https://www.nicewiczlaboratory.com/publications daily 0.75 2026-03-09 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/b19228df-dcef-423e-9cf8-2f6fe0a377f5/ZZ_AcridiniumTotalSynth+TOC.jpg Nicewicz Publications - 76. Integrated transient chromophores for efficient photo-induced radiofluorination Zhu, Z.; Huang, C.; Russell, R.; Kinon, P.; Ma, X.; Mao, Y.; Wu, X.; Wu, Z; Nicewicz, D.A.; Li, Z. Chem 2026, 102908. https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/04887124-b320-4fbd-aade-0ab7ec9a2287/JCG_RC_Synlett.jpg Nicewicz Publications - 75. A J-resolved 13C-19F {1H, 19F} Experiment with Broadband Fluorine Decoupling for the Characterization of Polyfluorinated Organic Compounds Genova, J.; Cabrera, R.; Nicewicz, D.A.; ter Horst, M. Synlett 2026 ASAPs https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/15ba5845-ea04-4742-9bcc-35386925be06/CO_BF_Semipinacol+TOC.jpg Nicewicz Publications - 74. Cation Radical-mediated Semi-pinacol and n+2 Ring Expansions via Organic Photoredox Catalysis Fulton, B.; Owen, C.; Nicewicz, D.A. Chem. Sci. 2026, 17, 4640-4648. https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/7045f5b1-1b6e-41cf-9b47-bde5320d8800/images_large_ol5c04049_0005.jpeg Nicewicz Publications - 73. One-Pot Bioisosteric Replacement of Alkyl Carboxylic Acids via Organic Photoredox Catalysis Haney, B.; Merriman, M.; Qian, S.; Nicewicz, D.A. Org. Lett. 2025 27 (43), 12194-12199 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/fc1dca36-dc19-4913-bbbf-ac1c7e05b2be/1-s2.0-S2451929425002372-fx1_lrg.jpg Nicewicz Publications - 72. Reductive coupling of Acrylamides and Carbonyls via Solvated Electrons from Excited-state Acridyl Radicals El Mokadem, R.K.; Lazarus, T.; Nicewicz, D.A. Chem 2025, 102647. https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/b394b392-60b0-4dbc-94a7-77a2f31c2c09/images_large_ja5c01788_0006.jpeg Nicewicz Publications - 71. Photochemically Enabled Total Syntheses of Stemoamide Alkaloids Akkawi, N.; Nicewicz, D.A. J. Am. Chem. Soc. 2025, 147, 18, 15482–15489 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/4e0c3ccb-e12e-485c-8e23-4eb783b56eb0/images_large_ar4c00837_0014.jpeg Nicewicz Publications - 70. Arene and Heteroarene Functionalization Enabled by Organic Photoredox Catalysis Zhu, Z.; Wu, X.; Li, Z.; Nicewicz, D.A. Acc. Chem. Res. 2025, 58, 1094–1108 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/ab742a72-a591-4e7c-a33b-7598c8dbc550/atropisomer.jpeg Nicewicz Publications - 69. Synthesis of Biaryl Atropisomers via Site-Selective C–H Functionalization Genova, J.; Nicewicz, D.A. Org. Lett., 2025, 27 (8), 1889-1894 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/0a6d9608-6c54-4704-a74e-77f12cb7b582/images_large_ja4c12028_0008.jpeg Nicewicz Publications - 68. Programmable Piperazine Synthesis via Organic Photoredox Catalysis Boley, A.; Genova, J.; Nicewicz, D.A.; J. Am. Chem. Soc. 2024, 146 (45), 31274-31280 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/1f1cd922-fe4a-4bd6-9e07-39f924c1c401/Screenshot+2024-11-01+at+9.26.11+AM.png Nicewicz Publications - 67. Carbon Isotopic Labelling of Carboxylic Acids Enabled By Organic Photoredox-Catalyzed Cyanation Zhu, Z.; Wu, X.; Bida, G.T.; Deng, H.; Ma, X.; Qian, S.; Wu, Z.; Li, Z.; Nicewicz, D.A. Nat. Synth., 2025, 4, 97-105. https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/50e5513c-925b-44cf-99ec-160c61fa190e/img.jpeg Nicewicz Publications - 66. One-Step Synthesis of [18F]Aromatic Electrophile Prosthetic Groups via Organic Photoredox Catalysis Li. M.; Staton, C.; Ma. X.; Zhao. W.; Pan. L.; Giglio.G.; Berton. H.S.; Wu. Z.; Nicewicz, D.A.; Li, Z. ACS. Cent. Sci., 2024, 10, 1609-1618 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/a3710bea-85d3-4901-9cca-5d535cc8873d/images_large_ja4c05052_0006.jpeg Nicewicz Publications - 65. Alkoxy Radical Generation Mediated by Sulfoxide Cation Radicals for Alcohol-Directed Aliphatic C–H Functionalization Finis, D.; Nicewicz, D. A.;. J. Am. Chem. Soc., 2024, 146, 24, 16830-16837 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/66438dd5-c65a-4d9a-9159-3591db3e8c4c/images_large_ja3c06936_0005.jpeg Nicewicz Publications - 64. Enantioselective Amino- and Oxycyanation of Alkenes via Organic Photoredox and Copper Catalysis Qian, S.; Lazarus, T.; Nicewicz, D.A. J. Am. Chem. Soc., 2023, 145, 33, 18247-18252 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/d5e1152e-910a-4f7c-a0aa-7c1705951ecd/i_b0534_ga_10-1055_a-2009-8279.gif Nicewicz Publications - 63. Divergent Functionalization of Alkynes Enabled by Organic Photoredox Catalysis Zhu, Z.; Qian, S.; Nicewicz, D. A.; Li, Z. Synlett. 2023 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/4ab80c65-0177-4158-aa3a-5e048bfffa07/1-s2.0-S2451929422006507-fx1_lrg.jpeg Nicewicz Publications - 62. 11C-, 12-C, and 13-C Cyanation of Electron-Rich Arenes via Organic Photoredox Catalysis Wu, X.; Chen, W.; Holmgberg-Douglas, N.; Bida, G.T.; Tu, X.; Ma, X.; Wu, Z.; Nicewicz, D.A.; Li, Z. Chem, 2023 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/be1fa9fb-8384-4ab8-ad83-701cefbebfa1/FmHhsr9aUAE4rN4.jpeg Nicewicz Publications - 61. Direct C-H Radiocyanation of Arenes via Organic Photoredox Catalysis Chen, W.; Wu, X.; McManus, J.B.; Bida, G.T.; Li, K.; Wu, Z.; Nicewicz, D. A.; Li, Z. Org. Lett. 2022, 24, 50, 9316-9321 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/615408e1-d779-47e1-bd03-aefa1415cf5c/FZz7ZtxVQAAfTBT.jpeg Nicewicz Publications - 60. Aliphatic C-H Functionalization Using Pyridine N-Oxides as H-Atom Abstraction Agents Schlegel, M.; Qian, S.; Nicewicz, D. A. ACS Catal. 2022, 12, 16, 10499–10505 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/6373f8d3-06a7-4683-aaae-34da1b4d5217/FZzZDoIUsAApeTb.jpeg Nicewicz Publications - 59. Mechanistic Investigation into Amination of Unactivated Arene via Cation Radical Accelerated Nucleophilic Aromatic Substitution Pistritto, V. A.; Liu, S..; Nicewicz, D. A. J. Am. Chem. Soc., 2022, 144, 33, 15118-15131 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/0f4a4cae-5ada-4390-bf1f-62ff91ce493d/FV9EF-xUAAAh7lE.jpeg Nicewicz Publications - 58. Ketone-Olefin Coupling of Aliphatic and Aromatic Carbonyl Catalyzed by Excited State Acridine Radicals Venditto, N.J.; Liang, Y.S.; El Mokadem, R.K.; Nicewicz, D. A. J. Am. Chem. Soc. 2022, 144, 26, 11888–11896 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/1646162976688-5EHV6JOAXW86LIUL1D31/PET1.001.jpeg Nicewicz Publications - 57. Arene Radiofluorination Enabled by Photoredox-Mediated Halide Interconversion Chen, W.; Wang, H.; Tay, N. E. S.; Pistritto, V. A.; Li, K.-P.; Wu, Z.; Nicewicz, D. A.; Li, Z. Nat. Chem, 2022, 14, 216-223 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/1646166066746-VROXKIRXFIDEBE9QEP0Y/paper+4.jpeg Nicewicz Publications - 56. Photoredox-Catalyzed C-H Functionalization Reactions Holmberg-Douglas, N.; Nicewicz, D. A. Chem. Rev. 2022, 122, 2, 1925–2016 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/1646166492040-WZK333LAZ40EJLTKE8PV/Screen+Shot+2022-03-01+at+3.27.52+PM.png Nicewicz Publications - 55. Diastereoselective Synthesis of the ABCD Ring System of Rubriflordilactone B Roth, H.G.; Nicewicz, D. A. Synlett. 2022, 33, 48–51 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/1646165384694-B7WCCK20URJSUK23TWXX/paper+2.jpeg Nicewicz Publications - 54. β-Functionalization of Saturated AzaHeterocycles Enabled by Organic Photoredox Catalysis Holmberg-Douglas, N.; Choi, Y.; Aquila, B.; Huynh, H.; Nicewicz, D. A. ACS Catal. 2021, 11, 3153-3158 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/7a1ffcb8-40fe-49fc-a8b9-e19bfa937ea6/Screenshot+2025-06-07+at+9.54.18%E2%80%AFPM.png Nicewicz Publications - 53. Milled Dry Ice as a C1 Source for the Carboxylation of Aryl Halides O’Brien, C. J.; Nicewicz, D. A. Synlett. 2021, 32, 814-816 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/1646164874978-GPOACT2RAA7GPYD1LZQ8/Screen+Shot+2022-03-01+at+3.00.18+PM.png Nicewicz Publications - 52. Direct Radiofluorination of Arene C–H Bonds via Photoredox Catalysis Using a Peroxide as the Terminal Oxidant Wang, L.; White, A. R.; Chen, W.; Wu, Z.; Nicewicz, D. A.; Li, Z. Org. Lett. 2020, 22, 7971-7975 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/086cfdbe-0943-47b8-8f74-3c6fa322933b/abstract_image_51.jpeg Nicewicz Publications - 51. Nucleophilic Aromatic Substitution of Unactivated Fluoroarenes Enabled by Organic Photoredox Catalysis Pistritto, V. A.; Schutzbach-Horton, M. E.; Nicewicz, D.A. J. Am. Chem. Soc. 2020, 142, 17187-17194. https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/8ca7ab2e-5293-4860-8b1e-0c82bd094b75/abstract_image_50.jpg Nicewicz Publications - 50. Direct Synthesis of Bicyclic Acetals via Visible Light Catalysis Wu, F.; Wang, L.; Ji, L.; Zou, G.; Shen, H.; Nicewicz, D.A.; Chen, J.; Huang, Y. iScience 2020, 23, 101395. https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/9c3dc90c-7f3c-475c-9d28-7da31166630e/abstract_image_49.jpeg Nicewicz Publications - 49. 19F- and 18F-Arene Deoxyfluorination via Organic Photoredox-Catalysed Polarity-Reversed Nucleophilic Aromatic Substitution Tay, N.E.S.; Chen W.; Levens, A.; Pistritto, V.A.; Huang, Z; Zhanhong, W.; Zibo, L.; Nicewicz, D.A. Nat. Catal. 2020, 3, 734-742 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/386154d7-6795-4f18-b584-0e628ad4c3bd/abstract_image_48.jpeg Nicewicz Publications - 48. Design and Evaluation of Artificial Hybrid Photoredox Biocatalysts Schwochert, T. D.; Cruz, C.; Watters, J. W.; Reynolds, E. W.; Nicewicz, D. A.; Brustad, E. ChemBioChem 2020, 21, 3146-3150. https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/a61814bd-e007-4871-a4d7-5b9dca0d384e/abstract_image_47.jpeg Nicewicz Publications - 47. Homobenzylic Oxygenation Enabled by Dual Organic Photoredox and Cobalt Catalysis McManus, J. B.*; Griffin, J. D.*; White, A. R.; Nicewicz, D. A. J. Am. Chem. Soc. 2020, 142, 23, 10325–10330 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/6899b744-1ad9-48d5-8725-a7fc7b556591/abstract_image_46.jpeg Nicewicz Publications - 46. Cation Radical-Accelerated Nucleophilic Aromatic Substitution for Amination of Alkoxyarenes Venditto, N. J.; Nicewicz, D. A. Org. Lett. 2020, 22, 12, 4817–4822 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/9ff14c38-54f5-4c44-9792-aa06cf455671/abstract_image_45.jpeg Nicewicz Publications - 45. Development of a Large-Enrollment Course-Based Research Experience in an Undergraduate Organic Chemistry Laboratory: Structure–Function Relationships in Pyrylium Photoredox Catalysts Cruz, C. L.; Holmberg-Douglas, N.; Onuska, N. P. R.; McManus, J. B.; MacKenzie, I. A.; Hudson, B.L.; Eskew, N. A.; Nicewicz, D. A. J. Chem. Educ. 2020, 97, 6, 1572–1578 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/5b5831ef-f21d-46ce-bb99-4e95b8364e5e/abstract_image_44.jpg Nicewicz Publications - 44. Discovery and Characterization of Acridine Radical Photoreductants. MacKenzie, I. A.; Wang, L.; Onuska, N. P. R.; Williams, O. F.; Begam, K.; Moran, A. M.; Dunietz, B. D.; Nicewicz, D. A. Nature, 2020, 580, 76-80. https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/2afbb074-9a83-4ba2-ad86-a1e6be76e4ba/abstract_image_43.jpg Nicewicz Publications - 43. Regioselective Arene C­–H Alkylation Enabled by Organic Photoredox Catalysis Holmberg-Douglas, N.; Onuska, N. P. R.; Nicewicz, D. A. Angew. Chem. Int. Ed. 2020, 59, 7425-7429 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/88ce5815-6837-4d99-9a68-6b8096e596ae/abstract_image_42.gif Nicewicz Publications - 42. Site-Selective C–H Alkylation of Piperazine Substrates via Organic Photoredox Catalysis. McManus, J. B.; Onuska, N. P. R.; Jeffreys, M. S.; Goodwin, N. C.; Nicewicz, D. A. Org. Lett. 2020, 22, 679-683 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/e97b255b-e28a-47fb-91e2-4fff39fd4488/abstract_image_41.jpg Nicewicz Publications - 41. Anti-Markovnikov Hydroazidation of Activated Olefins via Organic Photoredox Catalysis Onuska, N. P. R.; Schutzbach-Horton, M. E.; Rosario Collazo, J. L.; Nicewicz, D. A. Synlett, 2020, 31, 55-59 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/6e28612c-4ca3-4375-a04d-d6dd79b93d8a/abstract_image_40.jpg Nicewicz Publications - 40. Arene Cyanation via Cation Radical Accelerated Nucleophilic Aromatic Substitution Holmberg-Douglas, N.; Nicewicz, D. A. Org. Lett. 2019, 21, 7114-7118 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/79afd7db-1521-4cc4-a0b0-50feb978df44/abstract_image_39.jpg Nicewicz Publications - 39. Alcohol Mediated Degenerate Chain Transfer Controlled Cationic Polymerization of Para-Alkoxystyrene Prasher, A.; Hu, H.; Tanaka, J.; Nicewicz, D. A.; You, W. Polym. Chem. 2019, 10, 4126-4133 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/5e92d8b4-dec4-4c6c-8111-c2e42e3202d6/abstract_image_38.jpg Nicewicz Publications - 38. Arene C-H Fluorination with 18F– via Organic Photoredox Catalysis Chen, W.; Huang, Z.; Tay, N. E. S.; Giglio, B.; Wang, M.; Wang, H.; Wu, Z.; Nicewicz, D. A.; Li, Z. Science, 2019, 364, 1179-1174 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/9309dbba-f686-4054-a528-70399f90057a/abstract_image_36.jpg Nicewicz Publications - 37. Synthesis and Characterization of Acridinium Dyes for Photoredox Catalysis White, A. R.; Wang, L.; Nicewicz, D. A. Synlett 2019, 30, 827-832 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/839d960d-7b42-472e-9ea2-2d3fab12c45d/abstract_image_37.jpg Nicewicz Publications - 36. Mechanistic Investigations Into the Cation Radical Newman-Kwart Rearrangment Cruz, C. L.; Nicewicz, D. A. ACS Catal. 2019, 9, 3926-3935 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/827d6920-6c68-4ee3-b8cb-cee90ffc3892/abstract_image_35.jpg Nicewicz Publications - 35. Generation and Alkylation of α–Carbamyl Radicals via Organic Photoredox Catalysis McManus, J. B.; Onuska, N. P. R.; Nicewicz, D. A. J. Am. Chem. Soc. 2018, 140, 9056-9060 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/eea9e823-817b-43f0-ba17-4ea4f20c88a9/abstract_image_34.jpg Nicewicz Publications - 34. Enantioselective Counter Anions in Photoredox Catalysis: The Asymmetric Cation Radical Diels-Alder Reaction Morse, P. D.; Nguyen, T. M.; Cruz, C. L.; Nicewicz, D. A. Tetrahedron 2018, 74, 3266-3272 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/60b60f65-e823-4eb7-b045-a331df6b2afc/abstract_image_33.jpg Nicewicz Publications - 33. A General Strategy for Aliphatic C­–H Functionalization Enabled by Organic Photoredox Catalysis Margrey, K. A.; Czaplyski, W. L.; Nicewicz, D. A.; Alexanian, E. J. J. Am. Chem. Soc. 2018, 140, 4213-4217 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/27a11435-9bb4-4719-a079-6b036817d4ef/abstract_image_32.jpg Nicewicz Publications - 32. Direct Synthesis of Polysubstituted Aldehydes via Visible Light-Catalysis Wu, F.; Wang, L.; Chen, J.; Nicewicz, D. A.; Huang, Y. Angew. Chem. Int. Ed. 2018, 57, 2174-2178 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/1bd392aa-0102-4009-bd92-e9272dc16053/abstract_image_31.jpg Nicewicz Publications - 31. Cation Radical-Accelerated Nucleophilic Aromatic Substitution via Organic Photoredox Catalysis Tay, N. E.; Nicewicz, D. A. J. Am. Chem. Soc. 2017, 139, 16100-16104 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/d377db62-c94b-47de-8ff1-de20d7ba76fd/abstract_image_30.jpg Nicewicz Publications - 30. Direct C–H Arylation of Primary Amines via Organic Photoredox Catalysis Margrey, K. A.; Levens, A.; Nicewicz, D. A. Angew. Chem. Int. Ed. 2017, 56, 15644-15648 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/ba3b8dc1-370e-41bc-9394-bc6c94272fbc/abstract_image_29.jpg Nicewicz Publications - 29. Oxidation of Alkyl Benzenes by a Flavin Photooxidation Catalyst on Nano-Structured Metal Oxide Films Dongare, P.; MacKenzie, I; Wang, D.; Nicewicz, D. A.; Meyer, T. J. Proc. Natl. Acad. Sci. U.S.A. 2017, 114, 9279-9283 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/f93959cc-7ace-488e-891e-e7b3fd34c877/abstract_image_28.jpg Nicewicz Publications - 28. Predictive Model for Site-Selective Aryl and Heteroaryl C-H Amination via Organic Photoredox Catalysis Margrey, K. A.; McManus, J. B.; Bonazzi, S.; Zecri, F.; Nicewicz, D. A. J. Am. Chem. Soc. 2017, 139, 11288-11299 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/d79b5e3e-91bc-4bfd-8f91-a11a265584f5/abstract_image_27.jpg Nicewicz Publications - 27. Visible Light-Mediated [4+2] Cycloaddition of Styrenes: Synthesis of Tetralin Derivatives Wang, L.; Wu, F.; Chen, J.; Nicewicz, D. A.; Huang, Y. Angew. Chem. Int. Ed. 2017, 56, 6896-6900 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/9e2d4d0c-eefe-4b75-ba54-5d9a1685c43d/abstract_image_26.jpg Nicewicz Publications - 26. Direct C–H Cyanation of Arenes via Organic Photoredox Catalysis McManus, J. B.; Nicewicz, D. A. J. Am. Chem. Soc. 2017, 139, 2880-2883 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/0fac3085-04ca-4b7c-a4da-9024d0e8e526/abstract_image_25.jpg Nicewicz Publications - 25. Reversing the Regioselectivity of Halofunctionalization Reactions via Cooperative Photoredox and Copper Catalysis Griffin, J. D.; Cavanaugh, C. L.; Nicewicz, D. A. Angew. Chem. Int. Ed. 2017, 56, 2097-2100 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/9d8843f9-b26f-4029-aeaf-0ad745a2644d/abstract_image_24.jpg Nicewicz Publications - 24. A General Approach to Catalytic Alkene Anti-Markovnikov Hydrofunctionalization Reactions via Acridinium Photoredox Catalysis Margrey, K. A.; Nicewicz, D. A. Acc. Chem. Res. 2016, 49, 1997-2006 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/b41d008b-90ab-44d2-94bf-dac08a088aec/abstract_image_23.jpg Nicewicz Publications - 23. Acridinium-Based Photocatalysts: A Sustainable Option in Photoredox Catalysis Joshi-Pangu, A.; Lévesque, F.; Roth, H. G.; Oliver, S. F.; Campeau, L.-C.; Nicewicz, D., DiRocco, D. A. J. Org. Chem. 2016, 81, 7244-7249 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/73205e0e-50ca-4a37-9cc9-6f993d29f6ee/abstract_image_22.jpg Nicewicz Publications - 22. Organic Photoredox Catalysis Romero, N. A.; Nicewicz, D. A. Chem. Rev. 2016, 116, 10075-10166 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/77ce9657-dd78-4c86-a8cf-c0c6408e1084/abstract_image_21.jpg Nicewicz Publications - 21. Experimental and Calculated Electrochemical Potentials of Common Organic Molecules for Applications to Single Electron Redox Chemistry Roth, H. G.; Romero, N. A.; Nicewicz, D. A. Synlett, 2016, 27, 714-723 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/46eab5b3-8585-46fb-9730-21f4af63b8c2/abstract_image_20.jpg Nicewicz Publications - 20. An Ambient Temperature Newman-Kwart Rearrangement Mediated by Organic Photoredox Catalysis Perkowski, A. J.; Cruz, C. L.; Nicewicz, D. A. J. Am. Chem. Soc., 2015, 137, 15684-15687 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/294d43a9-0efd-4667-84ac-f956d6924b2e/abstract_image_19.jpg Nicewicz Publications - 19. Synthesis of a-Benzyloxyamino-g-Butyrolactones via a Polar Radical Crossover Cycloaddition Reaction Cavanaugh, C. L.; Nicewicz, D. A. Org. Lett., 2015, 17, 6082-6085 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/8b78cf91-8bc7-4b22-9721-9014e1e39557/abstract_image_18.jpg Nicewicz Publications - 18. Site-Selective Arene C­–H Amination via Photoredox Catalysis Romero, N. A.; Margrey, K. A.; Tay, N. E.; Nicewicz, D. A. Science, 2015, 349, 1326-1330 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/09cfb265-ffaa-44cf-9a36-6287bb6ac729/abstract_image_17.jpg Nicewicz Publications - 17. Hydrodecarboxylation of Carboxylic and Malonic Acid Derivatives via Organic Photoredox Catalysis: Substrate Scope and Mechanistic Insight Griffin, J. D.; Zeller, M. A.; Nicewicz, D. A. J. Am. Chem. Soc. 2015, 137, 11340-11348 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/4c406a1a-ab18-46c2-adcf-4035e2d6a905/abstract_image_16.jpg Nicewicz Publications - 16. Visible Light Photoinitiated Metal-Free Living Cationic Polymerization of 4-Methoxystyrene Perkowski, A. J.; You, W.; Nicewicz, D. A. J. Am. Chem. Soc. 2015, 137, 7580-7583 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/7de425f6-d445-474d-9ee6-3bc7db8315fa/abstract_image_15.jpg Nicewicz Publications - 15. Amide and Amine Nucleophiles in Polar Radical Crossover Cycloadditions: Synthesis of g-Lactams and Pyrrolidines Gesmundo, N. J.; Grandjean, J. M.; Nicewicz, D. A. Org. Lett. 2015, 17, 1316-1319 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/c8dfd22f-00fa-4123-b33d-6b0f65cb34c8/abstract_image_14.jpg Nicewicz Publications - 14. Divergent Regioselectivity in Photoredox-Catalyzed Hydrofunctionalization Reactions of Unsaturated Amides and Thioamides Morse, P. D.; Nicewicz, D. A. Chem. Sci. 2015, 6, 270-274 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/f58497e0-7d77-4adf-b28f-5921664de562/abstract_image_13.jpg Nicewicz Publications - 13. Mechanistic Insight into the Photoredox Catalysis of Anti-Markovnikov Alkene Hydrofunctionalization Reactions Romero, N.; Nicewicz, D. A. J. Am. Chem. Soc. 2014, 136, 17024-17035 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/4b0d9ef8-46d8-4fd0-bd74-31608b04d763/abstract_image_12.jpg Nicewicz Publications - 12. g-Butyrolactone Synthesis via Polar Radical Crossover Cycloaddition Reactions: Diastereoselective Synthesis of Methylenolactocin and Protolichesterinic Acid Zeller, M. A.; Riener, M.; Nicewicz, D. A. Org. Lett. 2014, 16, 4810-4813 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/e00c1f6d-7d32-4ebd-8ad1-6dab7d891310/abstract_image_11.jpg Nicewicz Publications - 11. Direct Anti-Markovnikov Addition of Mineral Acids to Styrenes Wilger, D. J.; Grandjean, J. M.; Lammert, T.; Nicewicz, D. A. Nature Chem. 2014, 6, 720-726 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/4d1145f2-58ef-41ea-8416-42020efd17af/abstract_image_10.jpg Nicewicz Publications - 10. Cyclization-Endoperoxidation Cascade Reactions of Dienes Mediated by a Pyrylium Photoredox Catalyst Gesmundo, N. J.; Nicewicz, D. A. Beilstein J. Org. Chem. 2014, 10, 1272-1281 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/18c9e24d-b087-48ba-b6c8-35224ffb23ea/abstract_image_09.jpg Nicewicz Publications - 9. Anti-Markovnikov Hydroamination of Alkenes Catalyzed by a Two-Component Organic Photoredox System: Direct Access to Phenethylamine Derivatives Nguyen, T. M.; Manohar, N.; Nicewicz, D. A. Angew. Chem. Int. Ed. 2014, 53, 6198-6201 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/da72bece-3a55-4ce9-a464-8af8ba987baa/abstract_image_08.jpg Nicewicz Publications - 8. Organic Photoredox Catalysis as a General Strategy for Anti-Markovnikov Hydrofunctionalization Nicewicz, D. A.; Hamilton, D. S. Synlett 2014, 25, 1191-1196 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/d1365763-4e11-4186-b8f6-6885178b9540/abstract_image_07.jpg Nicewicz Publications - 7. Recent Applications of Organic Dyes as Photoredox Catalysts Nicewicz, D. A.; Nguyen, T. M. ACS Catal. 2014, 4, 355-360 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/19d40068-5438-428f-bb8a-66014e818671/abstract_image_06.jpg Nicewicz Publications - 6. Direct Catalytic Anti-Markovnikov Addition of Carboxylic Acids to Alkenes Nicewicz, D. A.; Hamilton, D. S. J. Am. Chem. Soc. 2013, 135, 10334-10337 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/664d47a1-8c45-42eb-af75-161f114decfe/abstract_image_05.jpg Nicewicz Publications - 5. Anti-Markovnikov Hydroamination of Alkenes Catalyzed by an Organic Photoredox System Nguyen, T. M.; Nicewicz, D. A. J. Am. Chem. Soc. 2013, 135, 9588-9591 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/06c050e2-ce03-49e7-93cf-8cf04b8aa88f/abstract_image_04.jpg Nicewicz Publications - 4. Catalytic Hydrotrifluoromethylation of Styrenes and Unactivated Aliphatic Alkenes via an Organic Photoredox System Wilger, D. J.; Gesmundo, N. J.; Nicewicz, D. A.. Chem. Sci. 2013, 4, 3160-3165 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/ed92f391-dd1e-455a-bef1-0d33d8d0f7cf/abstract_image_03.jpg Nicewicz Publications - 3. Synthesis of Cyclobutane Lignans via an Organic Single Electron Oxidant-Electron Relay System Riener, M.; Nicewicz, D. A. Chem. Sci. 2013, 4, 2625-2629 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/ec7be353-de4b-450b-9d26-b63b3fc48425/abstract_image_02.jpg Nicewicz Publications - 2. Synthesis of Highly Substituted Tetrahydrofurans via Catalytic Polar-Radical Crossover Cycloadditions of Alkenes and Alkenols Grandjean, J.; Nicewicz, D. A. Angew. Chem. Int. Ed. 2013, 52, 3967-3971 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/a4e31c74-c3ea-41bc-96ce-2078e708d1bf/abstract_image_01.jpg Nicewicz Publications - 1. Direct Catalytic Anti-Markovnikov Hydroetherification of Alkenols Hamilton, D. S.; Nicewicz, D. A. J. Am. Chem. Soc. 2012, 134, 18577-18580 https://www.nicewiczlaboratory.com/home daily 1.0 2024-12-11 https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/12a354e3-af77-4cf3-97b4-899bc6a01379/IMG_0778.jpg Home https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/8e521304-c0ad-4387-98be-b989111defae/Screenshot+2024-12-11+at+1.20.13+PM.png Home https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/e93cf189-e4d5-4786-bdb3-8a4ac98a9743/Screenshot+2024-12-11+at+1.20.28+PM.png Home https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/3b0f35e3-d1f4-4ed1-bcc5-d204f67e8461/Photoredox2.jpg Home - Organic Photoredox Catalysis We study the use of organic molecules in the excited state to accomplish single electron redox chemistry https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/549859b0-edc4-49da-ac69-ae140266d20c/Reaction.jpg Home - New Reaction Development We seek to develop new sustainable chemical reactivity from common organic feedstocks https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/23513451-a8b3-45ec-82f1-7f4e88dca7cd/Mechanism_Main.001.jpg Home - Mechanistic Inquiry We use a variety of analytical techniques to study mechanism in photoredox reactions. https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/0a130ae3-4a37-4926-b313-49f76a6fcd87/Natural+Products.jpg Home - Natural Product Synthesis Applications of organic photoredox catalysis to natural product synthesis (coming soon…) https://images.squarespace-cdn.com/content/v1/62053f7c8926371c0debcc31/a0ab00eb-08c6-4a08-9251-da761a7a098f/Radiolabeling.001.jpg Home - Positron Emission Tomography We collaborate with Professor Zibo Li (UNC Radiology) to apply organic photoredox catalysis to radiolabeling and imaging